Ordering Recommendation

Aid as second order test for evaluation of patients suspected of humoral immunodeficiency or combined immunodeficiency (humoral or cellular).

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Serum separator tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 1 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Grossly hemolyzed or lipemic specimens

Remarks
Stability

After separation from cells: Ambient: Unacceptable; Refrigerated: 14 days; Frozen: 6 months

Methodology

Quantitative Immunoturbidimetry

Performed

Sun-Sat

Reported

1-3 days

Reference Interval

Test Number
Components
Reference Interval
  Immunoglobulin G Subclass 1
Age Reference Interval (mg/dL)
0-2 years 167-900
3-4 years 313-941
5-9 years 363-1276
10-14 years 316-1076
15-18 years 325-894
19 years and older 240-1118

  Immunoglobulin G Subclass 2
Age
Reference Interval (mg/dL)
0-2 years 55-359
3-4 years 72-287
5-9 years 27-398
10-14 years 86-509
15-18 years 156-625
19 years and older 124-549

  Immunoglobulin G Subclass 3
Age Reference Interval (mg/dL)
0-2 years 34-85
3-4 years 25-117
5-9 years 17-169
10-14 years 14-201
15-18 years 34-246
19 years and older 21-134

  Immunoglobulin G Subclass 4
Age
Reference Interval (mg/dL)
0-2 years 1-34
3-4 years 1-65
5-9 years 0-168
10-14 years 1-103
15-18 years 2-170
19 years and older 1-123

Interpretive Data

The total IgG (mg/dL) can be derived from the sum of the subclass IgG1, IgG2, IgG3, and IgG4 values. However, a confirmatory and more precise total IgG is available by the immunoturbidimetric method of quantitation for total IgG.  Refer to test Immunoglobulin G, Serum (0050350).

Compliance Category

FDA

Note

Hotline History

N/A

CPT Codes

82787 x4

Components

Component Test Code* Component Chart Name LOINC
0050571 Immunoglobulin G Subclass 1 2466-1
0050572 Immunoglobulin G Subclass 2 2467-9
0050573 Immunoglobulin G Subclass 3 2468-7
0050576 Immunoglobulin G Subclass 4 2469-5
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Gamma-Globulins, Quantitative
  • IgG 1, 2, 3, 4
  • IgG Subclasses
  • Subclasses, IgG
Immunoglobulin G Subclasses (1, 2, 3, 4)